The article treats of the double etiology of psychopathology. From the beginning Freud and Lacan stressed that repression is not the only cause. The article mainly considers the topic of the fixation of the drive (Freud) or the real jouissance (Lacan) as being the ultimate cause of psychopathological symptoms. Finally, it discusses Lacan’s final developments on the end of the analytical treatment. According to Lacan, the end of the analytical treatment or the removal of symptoms in a permannent way has to do with the relation from the subject to his jouissance.