Throughout the twentieth century, autism has been variously interpreted and as a result has become a flexible signifier. Over the last decade, both the academic world and popular culture have paid particular attention to the self-expression of people living on the spectrum. On the occasion of the most recent exhibition in the Dr. Guislain Museum in Ghent, which put numerous autistic artists in the spotlight, Leni Van Goidsenhoven reflects on conceptual changes within autism discourse, the danger of the savant-rhetoric, cultural interventions and the category of “autistic art”. She moreover shows how Museum Guislain’s project experiments with autism and outsider art by incorporating playful elements.