Responsibility is a crucial notion in psychoanalysis. This article begins with a discussion of the preliminary sessions and the installation of the supposed subject of knowledge as the clinical moment in which the analysand takes up responsibility for his suffering. The second part of this article deals with the fate of the subject supposed to know in analysis as illustrated by the author’s testimony of a moment of pass in his own analysis. The analysis of two crucial dreams proves both the intransigence of a religious dimension in transference and the responsibility of the analyst in this matter. The final section of this article discusses the way in which this religious dimension can creep into and undermine psychoanalytical associations.